MR Imaging–Pathologic Correlation of Uveal Melanomas Undergoing Secondary Enucleation after Proton Beam Radiotherapy

Background: Currently, radiotherapy represents the most widely employed therapeutic option in patients with uveal melanoma. Although effects of proton beam on melanoma end ocular tissues have been histologically documented, their appearance at MR imaging is still poorly understood. The purpose our study was to elucidate magnetic resonance (MR) semiotics radiotherapy-induced changes neoplastic and structures undergoing secondary enucleation after radiotherapy. Methods: Nine who had undergone radiotherapy, imaging, subsequent were retrospectively selected. histopathologic findings evaluated for irradiated tumors necrosis, fibrosis, viable tumor, while extratumoral ocular/periocular radiation-related intraocular inflammation, vitreous hemorrhage, optic nerve degeneration, iris neovascularization, periocular fibrotic adhesions. On images, abovementioned histologic features assessed conventional diffusion-weighted sequences. Results: T2-weighted sequences performed better detecting radiation-induced T1-weighted preferable identifying cataracts, inflammatory complications. Contrast-enhanced irreplaceable assessing confirming Conclusions: In light increasing role multidisciplinary management melanoma, radiologists should be aware tissue, order improve accuracy follow-up examinations.